BDBM50109821 CHEBI:87103::CHEMBL21156::US10981896, Compound 420099
SMILES CC(C)(C)c1nc2c([nH]1)c1cc[nH]c(=O)c1c1cc(F)ccc21
InChI Key InChIKey=VNDWQCSOSCCWIP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50109821
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of FynT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of JAK3 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Tyk2 (unknown origin) using 1 mM of ATP and Tyr3 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin) using 87 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin) using 35 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK3 (unknown origin) using 16 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of Tyk2 (unknown origin) using 25 uM of ATP and Tyr3 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin
Curated by ChEMBL
The University Of Texas At Austin
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin
Curated by ChEMBL
The University Of Texas At Austin
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2 (835 to 1132 residues)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of JAK1 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair