BDBM50109821 CHEBI:87103::CHEMBL21156::US10981896, Compound 420099

SMILES CC(C)(C)c1nc2c([nH]1)c1cc[nH]c(=O)c1c1cc(F)ccc21

InChI Key InChIKey=VNDWQCSOSCCWIP-UHFFFAOYSA-N

Data  25 IC50

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50109821   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human JAK2 (835 to 1132 residues)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  300nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  500nMAssay Description:Inhibition of FynT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed