BDBM50126829 (E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl)-3-phenylprop-2-en-1-one::1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl)-3-phenylprop-2-en-1-one::1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenyl-propenone::CHEMBL34241::R5648 (Rottlerin)::ROTTLERIN

SMILES: CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)C=Cc3ccccc3)c2O)c1O

InChI Key: InChIKey=DEZFNHCVIZBHBI-UHFFFAOYSA-N

Data: 14 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50126829   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C alpha type/glutamine gamma-glutamyltransferase 2 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	37
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Beta-lactamase (Enterobacter cloacae)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-lactamase (Enterobacter cloacae)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Eukaryotic elongation factor 2 kinase (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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RuvB-like 1 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C delta type (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 5 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 2 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-lactamase (Escherichia coli (strain K12))	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Chymotrypsinogen B (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Malate dehydrogenase (Thermus thermophilus)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 5 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C delta type (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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WD repeat-containing protein 48 (Human)	BDBM50126829 ((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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