BDBM50136674 (3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine::(3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine::(R)-duloxetine::CHEMBL336920::LY248685

SMILES CNCC[C@@H](Oc1cccc2ccccc12)c1cccs1

InChI Key InChIKey=ZEUITGRIYCTCEM-QGZVFWFLSA-N

Data  8 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50136674   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  8.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNorepinephrine transporter(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  15.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  61.3nMAssay Description:Displacement of [125I]RTI-55 from human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  550nMAssay Description:Displacement of [125I]RTI-55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataKi:  659nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataIC50:  809nMAssay Description:Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataIC50:  13.2nMAssay Description:Inhibition of [3H]NE reuptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propa...)
Affinity DataIC50:  660nMAssay Description:Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed