BDBM50151661 CHEMBL3752296
SMILES COc1ccc2CCCN(CCCNC(=O)c3cccc4NC(=O)[C@@H](C)Nc34)c2c1
InChI Key InChIKey=FBGWKDHQIRVFSD-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50151661
Affinity DataKd: 390nMAssay Description:Inhibition of human His6-tagged CREBBP expressed in competent Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to human BRD4 bromodomain 1More data for this Ligand-Target Pair
Affinity DataIC50: 323nMAssay Description:Inhibition of CBP (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataKd: 390nMAssay Description:Binding affinity to CBP (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of biotinylated ligand from BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated CBP (unknown origin) expressed in HEK293 cells after overnight incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 323nMAssay Description:Inhibition of CBP (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Binding affinity to BRD4 bromodomain 1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.390nMAssay Description:Binding affinity to CREBBP (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Affinity DataKd: 353nMAssay Description:Binding affinity to human CREBBP bromodomain expressed in Escherichia coli BL21 (DE3)-RIL assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 323nMAssay Description:Inhibition of CREBBP (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
Affinity DataKd: 316nMAssay Description:Binding affinity to human CREBBP bromodomain expressed in Escherichia coli BL21 (DE3)-RILMore data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Inhibition of human CREBBPMore data for this Ligand-Target Pair
Affinity DataKd: 1.01E+3nMAssay Description:Binding affinity to human BRD4 bromodomain 1 assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Inhibition of human BRD4 by isothermal titration calorimetryMore data for this Ligand-Target Pair