BDBM50341209 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1765602

SMILES: Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1

InChI Key: InChIKey=GUXXEUUYCAYESJ-UHFFFAOYSA-N

Data: 18 IC50  6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50341209   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Mouse)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	8.60	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase alpha (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine-protein kinase ATM (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine-protein kinase ATM (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Target of rapamycin complex subunit LST8 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Target of rapamycin complex subunit LST8 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Target of rapamycin complex 2 subunit MAPKAP1 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Target of rapamycin complex subunit LST8 (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.70	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.70	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Human)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair