BDBM50425829 CHEMBL2312304
SMILES Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)c1
InChI Key InChIKey=XYASHXPUZJDWIO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 48 hits for monomerid = 50425829
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 775nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.99E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of VEGFR2/FLK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.71E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TAOK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKd: 4.60nMAssay Description:Binding affinity to human CASK by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKd: 770nMAssay Description:Binding affinity to human CSNK1E by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding affinity to human MERTK by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
Affinity DataKd: 740nMAssay Description:Binding affinity to human non-phosphorylated ABL1 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKd: 1.30E+3nMAssay Description:Binding affinity to human N-terminal RSK3 kinase domain 1 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKd: 690nMAssay Description:Binding affinity to human MAP3K2 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
Affinity DataKd: 800nMAssay Description:Binding affinity to human MET by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.70E+3nMAssay Description:Binding affinity to human AXL by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataKd: 87nMAssay Description:Binding affinity to recombinant N-terminal His-tagged CASK (1 to 337 residues) (unknown origin) expressed in Escherichia coli assessed as dissociatio...More data for this Ligand-Target Pair
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main
Curated by ChEMBL
Goethe University Frankfurt Am Main
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused MERTK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused AXL (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused ABL1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair