BDBM50425829 CHEMBL2312304

SMILES Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)c1

InChI Key InChIKey=XYASHXPUZJDWIO-UHFFFAOYSA-N

Data  2 KI  37 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50425829   

TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKi:  15nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKi:  120nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  775nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  3.99E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of VEGFR2/FLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  7.71E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TAO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TAOK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  4.09E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  70nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  70nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to human CASK by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  770nMAssay Description:Binding affinity to human CSNK1E by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  570nMAssay Description:Binding affinity to human MERTK by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  740nMAssay Description:Binding affinity to human non-phosphorylated ABL1 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human N-terminal RSK3 kinase domain 1 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  690nMAssay Description:Binding affinity to human MAP3K2 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  800nMAssay Description:Binding affinity to human MET by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human AXL by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataKd:  87nMAssay Description:Binding affinity to recombinant N-terminal His-tagged CASK (1 to 337 residues) (unknown origin) expressed in Escherichia coli assessed as dissociatio...More data for this Ligand-Target Pair
TargetPeripheral plasma membrane protein CASK(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  130nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused CASK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  700nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused MERTK (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused AXL (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer K5 binding to NanoLuc-fused ABL1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed