BDBM50439517 CHEMBL2418349

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@@H]2CC)c2n(C)ncc2n1

InChI Key InChIKey=DFFHBQFOKXDZFK-INIZCTEOSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50439517   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50439517(CHEMBL2418349)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant mTOR (1360-2549) expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 after 30 mins by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50439517(CHEMBL2418349)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of TAMRA-PIP3 from PI3Kalpha GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50439517(CHEMBL2418349)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of TAMRA-PIP3 from PI3Kdelta GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50439517(CHEMBL2418349)
Affinity DataIC50:  8nMAssay Description:Inhibition of mTOR in PTEN deficient human PC3 cells assessed as inhibition of Akt phosphorylation at Ser473More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50439517(CHEMBL2418349)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTOR in PTEN deficient human PC3 cells assessed as inhibition of p70S6K phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed