BDBM50442991 CHEMBL432537::GNF-Pf-3777::US10669273, Compound 5i
SMILES [O-][N+](=O)c1ccc-2c(c1)C(=O)c1nc3ccccc3c(=O)n-21
InChI Key InChIKey=UFMQJYHLIUACCG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50442991
Affinity DataKi: 54nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 215nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Uncompetitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of va...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IDO2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynu...More data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair