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Found 4 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50442991'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataKi:  54nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  0.0180nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  103nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  550nMAssay Description:Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...More data for this Ligand-Target Pair
In DepthDetails US Patent