BDBM50567579 Encequidar::HM-30181::HM30181::HM30181AK::Pgp inhibitor hm30181ak::US11739089, Compound Encequidar

SMILES: COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC

InChI Key: InChIKey=AHJUHHDDCJQACA-UHFFFAOYSA-N

Data: 10 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50567579   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 2 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Broad substrate specificity ATP-binding cassette transporter ABCG2 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Multidrug resistance-associated protein 1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50567579 (Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair