BDBM14754 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline::1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline::6,7-dimethoxy-1-veratryl-isoquinoline;hydrochloride::CHEMBL19224::Papaverine

SMILES: COc1ccc(cc1OC)Cc2c3cc(c(cc3ccn2)OC)OC

InChI Key: InChIKey=XQYZDYMELSJDRZ-UHFFFAOYSA-N

Data: 6 KI  47 IC50  2 EC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 14754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	917	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rat)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphodiesterase (Pig)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
3',5'-cyclic-AMP phosphodiesterase (Pig)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	284	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bile salt export pump (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein RecA (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein RecA (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.01E+3	n/a	n/a	n/a	n/a
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Protein-arginine deiminase type-4 (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphodiesterase (Trypanosoma cruzi)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 2 (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 4 (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 3 (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rat)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
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Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5.89E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Acetylcholinesterase (Electric eel)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rat)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rat)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	287	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rat)	BDBM14754 (CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...) Show SMILES Show InChI	GoogleScholar	UniChem		17	-10.5	n/a	n/a	n/a	n/a	n/a	7.5	22
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