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Found 56 with Last Name = 'karim' and Initial = 'ka'
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.29nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  6.14nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  25.1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50:  26.7nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  40.7nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50:  42.8nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36354(4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataIC50:  108nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  148nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Affinity DataIC50:  161nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  215nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  235nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  565nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50:  998nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  1.12E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50:  1.58E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50:  1.94E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50:  2.06E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50:  2.42E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50:  3.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Affinity DataIC50:  3.56E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Affinity DataIC50:  8.04E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.06E+4nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Vanderbilt University

LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  1.08E+4nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36354(4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataEC50:  2.50E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataEC50:  5.00E+3nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5294(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36353(dorsomorphin (91E))
Affinity DataEC50:  5.00E+3nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5416(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36352(dorsomorphin (6LE))
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataEC50:  2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Affinity DataEC50:  1.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataEC50: >5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataEC50: >5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36354(4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataEC50: >5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5294(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Affinity DataEC50: >5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36353(dorsomorphin (91E))
Affinity DataEC50:  2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM5416(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataEC50:  5.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36352(dorsomorphin (6LE))
Affinity DataEC50:  5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  2.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataEC50:  5.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataEC50:  1.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36355(4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataEC50:  100nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM36354(4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataEC50:  200nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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