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Found 360 with Last Name = 'liu' and Initial = 'jo'
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112356(CHEMBL3609373)
Affinity DataKi:  510nMAssay Description:Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50420258(CEFSULODIN)
Affinity DataKi:  6.60E+3nMAssay Description:Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36597(FOS-69)
Affinity DataIC50:  0.100nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36589(Ovalicin)
Affinity DataIC50:  0.400nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM50131562(CHEMBL117603 | Deca-2,4,6,8-tetraenedioic acid mon...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36588(AGM-1470)
Affinity DataIC50:  1nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36595(FOS-68)
Affinity DataIC50:  2nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36592(FOS-70)
Affinity DataIC50:  3.5nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088483(CHEMBL1835951)
Affinity DataIC50:  4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088484(CHEMBL1835950)
Affinity DataIC50:  4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088485(CHEMBL1835949)
Affinity DataIC50:  4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088486(CHEMBL454471)
Affinity DataIC50:  4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36596(FOS-34)
Affinity DataIC50:  4nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36590(FOS-72)
Affinity DataIC50:  6nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36591(FOS-37)
Affinity DataIC50:  8nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088480(CHEMBL1835953)
Affinity DataIC50:  16nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrates after 5 mins by LC/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088481(CHEMBL1835952)
Affinity DataIC50:  17nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrates after 5 mins by LC/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088479(CHEMBL1835954)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrates after 5 mins by LC/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088455(CHEMBL1835955)
Affinity DataIC50:  26nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrates after 5 mins by LC/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36599(FOS-201)
Affinity DataIC50:  45nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435227(CHEMBL2392772)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50052428(2-(2,6-Dioxo-piperidin-3-yl)-4,5,6,7-tetrafluoro-i...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against TNF-alpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435224(CHEMBL2392893)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435217(CHEMBL2392900)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435226(CHEMBL2392891)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435219(CHEMBL2392898)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435218(CHEMBL2392899)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50433375(CHEMBL472879 | GNF-Pf-359)
Affinity DataIC50:  860nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435229(CHEMBL2392771)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435228(CHEMBL460432)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435225(CHEMBL2392892)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435223(CHEMBL2392894)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435220(CHEMBL2392897)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112358(CHEMBL3609374)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435222(CHEMBL2392895)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM17847(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435231(CHEMBL2392769)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112356(CHEMBL3609373)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435221(CHEMBL2392896)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM68281(Bengamide A)
Affinity DataIC50:  1.90E+3nMAssay Description:The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50433377(CHEMBL2375628)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Plasmodium falciparum)
Johns Hopkins School Of Medicine

LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50:  2.00E+3nMAssay Description:Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112357(CHEMBL3609375)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50541823(CHEMBL4644787)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM68286(Bengamide N | Bengamide O)
Affinity DataIC50:  2.70E+3nMAssay Description:The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM17849(3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...)
Affinity DataIC50:  2.90E+3nMpH: 7.5 T: 2°CAssay Description:The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...More data for this Ligand-Target Pair
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50448482(CHEMBL3126408)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of DNA polymerase-gamma (unknown origin) assessed as incorporation of Br(d)UTP by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112358(CHEMBL3609374)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of phosphatase activity of human PTP1B using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Massachusetts Institute Of Technology

LigandPNGBDBM36593(FOS-64)
Affinity DataIC50:  3.00E+3nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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