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Found 319 with Last Name = 'orfi' and Initial = 'l'
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50305083(3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,...)
Affinity DataIC50:  5nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010383(CHEMBL3263959)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly-AEKY peptide as substrate after 60 mins by ADPGlo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010382(CHEMBL3263958)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly-AEKY peptide as substrate after 60 mins by ADPGlo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly-AEKY peptide as substrate after 60 mins by ADPGlo assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15978(2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino...)
Affinity DataIC50:  9nMAssay Description:Inhibition of JNK1alpha1 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using poly-GT peptide as substrate by Transcreener assayMore data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50315887((1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidaz...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant INSR (unknown origin) using fluorescent dye-labelled KKSRGDYMTMQIG peptide peptide as substrate after 1 hr by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15993(2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino...)
Affinity DataIC50:  25nMAssay Description:Inhibition of JNK1alpha1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15997(2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)...)
Affinity DataIC50:  28nMAssay Description:Inhibition of JNK1alpha1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013509(CHEMBL3263770)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) expressed in HEK293 cells using GST-CTDII as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010383(CHEMBL3263959)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant INSR (unknown origin) using fluorescent dye-labelled KKSRGDYMTMQIG peptide peptide as substrate after 1 hr by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-2(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM50168247(2,3-Di-thiophen-2-yl-benzo[g]quinoxaline-7-carboxy...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15993(2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino...)
Affinity DataIC50:  40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013510(CHEMBL3263773)
Affinity DataIC50:  44nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using MBP peptide substrate after 1 hr by FRET-based LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15997(2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013602(CHEMBL3263772)
Affinity DataIC50:  52nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) expressed in HEK293 cells using GST-CTDII as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389576(N-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinaz...)
Affinity DataIC50:  74nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010386(CHEMBL3263962)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using poly-GT peptide as substrate by Transcreener assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010388(CHEMBL3263964)
Affinity DataIC50:  94nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using poly-GT peptide as substrate by Transcreener assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013507(CHEMBL3263769)
Affinity DataIC50:  129nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389583(N-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- ...)
Affinity DataIC50:  134nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013492(CHEMBL3264159)
Affinity DataIC50:  142nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013483(CHEMBL3264150)
Affinity DataIC50:  143nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013491(CHEMBL3264158)
Affinity DataIC50:  163nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010387(CHEMBL3263963)
Affinity DataIC50:  168nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using poly-GT peptide as substrate by Transcreener assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50010382(CHEMBL3263958)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant INSR (unknown origin) using fluorescent dye-labelled KKSRGDYMTMQIG peptide peptide as substrate after 1 hr by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM15978(2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino...)
Affinity DataIC50:  170nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013508(CHEMBL3263771)
Affinity DataIC50:  170nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADPH oxidase 4(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50326495(2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)ph...)
Affinity DataIC50:  170nMAssay Description:Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013487(CHEMBL3264154)
Affinity DataIC50:  186nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013437(CHEMBL3264107)
Affinity DataIC50:  197nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  200nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013481(CHEMBL3264148)
Affinity DataIC50:  210nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013490(CHEMBL3264157)
Affinity DataIC50:  212nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADPH oxidase 4(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50326485(CHEMBL1243033 | N-4-(3-Amino-phenyl)-benzo[4,5]thi...)
Affinity DataIC50:  240nMAssay Description:Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389615(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Affinity DataIC50:  246nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013480(CHEMBL3264147)
Affinity DataIC50:  248nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013479(CHEMBL3264146)
Affinity DataIC50:  254nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389591(N'-{2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-...)
Affinity DataIC50:  258nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNADPH oxidase 4(Homo sapiens (Human))
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50326494(2,3,8,9-tetrahydroxy-5-(3-nitrobenzyl)phenanthridi...)
Affinity DataIC50:  260nMAssay Description:Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013456(CHEMBL3264124)
Affinity DataIC50:  261nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataIC50:  280nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013438(CHEMBL3264108)
Affinity DataIC50:  296nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389604(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylsulfonyl)phen...)
Affinity DataIC50:  326nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013443(CHEMBL3264113)
Affinity DataIC50:  327nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013598(CHEMBL3263805)
Affinity DataIC50:  332nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013595(CHEMBL3263802)
Affinity DataIC50:  333nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013455(CHEMBL3264123)
Affinity DataIC50:  346nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Vichem Chemie

Curated by ChEMBL
LigandPNGBDBM50013586(CHEMBL3263793)
Affinity DataIC50:  360nMAssay Description:Inhibition of CDK9/CycT1 (unknown origin) using TAMRA-Rbtide and ATP as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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