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Found 677 with Last Name = 'ouyang' and Initial = 'l'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513209(CHEMBL4440151)
Affinity DataKi:  0.880nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM24466(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513206(CHEMBL4546186)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513205(CHEMBL4437666)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593636(CHEMBL5192732)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to BRD4-BD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM190196(EPZ008277 | US9175331, 25)
Affinity DataKi:  3nMAssay Description:Binding affinity to EZH2 mutant (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM190196(EPZ008277 | US9175331, 25)
Affinity DataKi:  3nMAssay Description:Binding affinity to wild-type EZH2 (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKi:  4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.5nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593636(CHEMBL5192732)
Affinity DataKi:  79nMAssay Description:Binding affinity to BRD4-BD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420273(CHEMBL2089208)
Affinity DataKi:  89nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420268(CHEMBL2089203)
Affinity DataKi:  91nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50339398((+)-R-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Affinity DataKi:  170nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513207(CHEMBL4566706)
Affinity DataKi:  400nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513201(CHEMBL4447592)
Affinity DataKi:  600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50148573((E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-ben...)
Affinity DataKi:  710nMAssay Description:Binding affinity to N-terminal 6His-tagged recombinant human DHODH expressed in Escherichia coli strain BL21 (DE3) by isothermal titration calorimetr...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of human VEGFR-2 using poly(Glu, Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PARP2 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149945(CHEMBL3770205)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50234890(CHEMBL4077018)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Met (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50605409(CHEMBL5209870)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BRD4 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590378(CHEMBL5200425)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using monomethylated H3K27 as substrate by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of EZH2 in human HCT-116 cells assessed as inhibition of H3K27me3 incubated for 3 days by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PARP1 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of EZH2 in human HCT-116 cells assessed as inhibition of H3K27me3 incubated for 3 days by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513200(CHEMBL4514512)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146166(CHEMBL3765306)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of VEGF induced VEGFR2 phosphorylation in HUVEC after 5 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of KDR (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146165(CHEMBL3764474)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Met (unknown origin) by tumor cell growth inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399538(BAY-579352 | CHEMBL2079588)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50:  1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513203(CHEMBL4539285)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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