Affinity DataKi: 0.0450nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity to BRD4-BD2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity to EZH2 mutant (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity to wild-type EZH2 (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Binding affinity to BRD4-BD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 89nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 355nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataKi: 710nMAssay Description:Binding affinity to N-terminal 6His-tagged recombinant human DHODH expressed in Escherichia coli strain BL21 (DE3) by isothermal titration calorimetr...More data for this Ligand-Target Pair
Affinity DataKi: 8.50E+3nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human VEGFR-2 using poly(Glu, Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PARP2 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
School Of Medicine Of University Of Electronic Science And Technology Of China
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics
Curated by ChEMBL
National Clinical Research Center For Geriatrics
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Met (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRD4 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using monomethylated H3K27 as substrate by radiometric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of EZH2 in human HCT-116 cells assessed as inhibition of H3K27me3 incubated for 3 days by AlphaLISA assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP1 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 0.620nMAssay Description:Inhibition of EZH2 in human HCT-116 cells assessed as inhibition of H3K27me3 incubated for 3 days by AlphaLISA assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics
Curated by ChEMBL
National Clinical Research Center For Geriatrics
Curated by ChEMBL
Affinity DataIC50: 0.75nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre
Curated by ChEMBL
Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Inhibition of VEGF induced VEGFR2 phosphorylation in HUVEC after 5 mins by Western blot analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of KDR (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
National Clinical Research Center For Geriatrics
Curated by ChEMBL
National Clinical Research Center For Geriatrics
Curated by ChEMBL
Affinity DataIC50: 0.980nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Met (unknown origin) by tumor cell growth inhibition assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescent assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital
Curated by ChEMBL
Sichuan Universitt China Hospital
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair