BDBM139658 US8894989, 37
SMILES O=c1[nH]nc2[nH]c(CN3Cc4ccccc4C3)nc3cccc1c23
InChI Key InChIKey=JLFSBHQQXIAQEC-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 139658
Affinity DataIC50: 12nMpH: 8.0Assay Description:A convenient method to determine IC50 of a PARP inhibitor compound is a PARP assay using purified recombinant human PARP from Trevigan (Gaithersburg,...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PARP2 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human PARP1 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1 by chemiluminescent assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant TNKS2 by chemiluminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mouse recombinant PARP-2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS2More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse recombinant PARP2More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP-1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1/TNKS2 (unknown origin) by chemiluminescent assayMore data for this Ligand-Target Pair