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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

Ki: 300nMMore data for this Ligand-Target Pair

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Aldo-keto reductase family 1 member C3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50546239(CHEMBL103579)

Ki: 5.50E+3nMAssay Description:Inhibition of human AKR1C3 expressed in Escherichia coli incubated for 30 mins in presence of NADPH regeneration system by UHPLC analysisMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Universite De Lyon

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMAssay Description:Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATPMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 4nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair

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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 30nMAssay Description:Inhibition of CDK2-cyclinA in the presence of 20uM ATPMore data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 30nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 35nMAssay Description:Inhibition of human cdk2/cyclin EMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 35nMAssay Description:Inhibition of Cyclin E-cyclin-dependent kinase 2More data for this Ligand-Target Pair

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Cdc2(Asterina pectinifera)
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 40nMAssay Description:Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 150 M [gamma32P]ATPMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 50nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 50nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair

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Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMAssay Description:Inhibition of Cyclin A-cyclin-dependent kinase 2More data for this Ligand-Target Pair

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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair

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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair

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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMAssay Description:Inhibition of recombinant CDK2/CycA (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMAssay Description:Inhibition of human cdk2/cyclin AMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by PDSP K_i Database

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 70nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair

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Cyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Universite De Lyon

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 75nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 75nMAssay Description:Inhibition of recombinant CDK5/p35 (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 75nMAssay Description:Inhibition of human cdk5/p35More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 80nMAssay Description:Inhibition of Saccharomyces cerevisiae cdc28More data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 4(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 130nMAssay Description:Inhibition of PAK4 in the presence of 5uM ATPMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 240nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 240nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 300nMAssay Description:Inhibition of DYRK1A (unknown origin) by cell-based assayMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 340nMAssay Description:Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATPMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50093397((R){1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-pur...)

IC50: 430nMAssay Description:Inhibition of Cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

Cdc2(Asterina pectinifera)
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 500nMAssay Description:Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 1.5 mM [gamma32P]ATPMore data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Universite De Lyon

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 610nMAssay Description:Inhibition of recombinant human full length His-tagged CDK1/Cyclin B expressed in baculovirus expression system using peptide substrate after 30 mins...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 850nMAssay Description:Inhibition of Cyclin D1-cyclin-dependent kinase 4More data for this Ligand-Target Pair

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Cyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 850nMAssay Description:Inhibition of human cdk4/cyclin D1More data for this Ligand-Target Pair

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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 850nMAssay Description:Inhibition of recombinant CDK4/CycD1 (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 850nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.59E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair

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Cyclin-dependent protein kinase PHO85(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 2.00E+3nMAssay Description:Inhibition of yeast W303 Pho85 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation countingMore data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 5.00E+3nMAssay Description:Inhibition of human insulin receptorMore data for this Ligand-Target Pair

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Aldo-keto reductase family 1 member C3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50546239(CHEMBL103579)

IC50: 6.58E+3nMAssay Description:Inhibition of human AKR1C3 expressed in Escherichia coli incubated for 30 mins in presence of NADPH regeneration system by UHPLC analysisMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 7.00E+3nMAssay Description:Inhibition of yeast W303 cdc28 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation countingMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 9.00E+3nMAssay Description:Inhibition of human Erk1More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 9.00E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)More data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 9.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinaseMore data for this Ligand-Target Pair

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Protein kinase C gamma type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+4nMAssay Description:Inhibition of human PKCgammaMore data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+4nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+4nMAssay Description:Inhibition of human PKCalphaMore data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+4nMAssay Description:Inhibition of human PKCbeta1More data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+4nMAssay Description:Inhibition of human PKCbeta2More data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.10E+4nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.13E+4nMAssay Description:Inhibition of Mer kinaseMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.13E+4nMAssay Description:Inhibition of MER (588 to 855) (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.13E+4nMAssay Description:Inhibition of N-terminal His-tagged Mer kinase (588 to 855 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells measured every mi...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50132193(2-[8-Chloro-6-(3-chloro-phenylamino)-9-isopropyl-9...)

IC50: 1.30E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Interferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 1.60E+4nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair

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Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM50113680((R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-puri...)

IC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM50113682(3-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

MO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 2.60E+4nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair

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MO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research

Curated by ChEMBL

BDBM50154615(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 2.60E+4nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 3.50E+4nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: 3.50E+4nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113684(2-[6-(4-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 8.00E+4nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Protein kinase C zeta type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+5nMAssay Description:Inhibition of human PKCzetaMore data for this Ligand-Target Pair

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Protein kinase C eta type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+5nMAssay Description:Inhibition of human PKCetaMore data for this Ligand-Target Pair

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Protein kinase C delta type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+5nMAssay Description:Inhibition of human PKCdeltaMore data for this Ligand-Target Pair

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Protein kinase C epsilon type(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)

IC50: >1.00E+5nMAssay Description:Inhibition of human PKCepsilonMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: 2.20E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113729(2-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

IC50: 2.20E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113682(3-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

IC50: 2.30E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113747(2-(9-Isopropyl-6-phenylamino-9H-purin-2-ylamino)-3...)

IC50: 2.40E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113680((R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-puri...)

IC50: 3.00E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113749(2-[6-(3-Chloro-4-fluoro-phenylamino)-9-isopropyl-9...)

IC50: 3.60E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113728(CHEMBL305823 | {1-[6-(3-Chloro-phenylamino)-9-isop...)

IC50: 5.00E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113746(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 5.00E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Serine/threonine-protein kinase CAK1(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: >5.00E+5nMAssay Description:Inhibition of yeast W303 Cak1 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation countingMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Serine/threonine-protein kinase KIN28(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: >5.00E+5nMAssay Description:Inhibition of yeast W303 Kin28 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation countingMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Meiotic mRNA stability protein kinase SSN3(Saccharomyces cerevisiae)
University Of California

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

IC50: >5.00E+5nMAssay Description:Inhibition of yeast W303 Srb10 phosphorylation assessed as [32P] incorporation in histone H1 from [gamma32P]ATP by scintillation countingMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113704(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 5.00E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113696(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 5.30E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50093397((R){1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-pur...)

IC50: 6.20E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113745(3-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 9.00E+5nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113752(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 2.30E+6nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113717(2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

IC50: 5.00E+6nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113701(2-{[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

IC50: 5.00E+6nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113681(2-{[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

IC50: 5.30E+6nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113730(2-[6-(4-Amino-3-chloro-phenylamino)-9-isopropyl-9H...)

IC50: 3.30E+7nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50113693(2-[6-(3-Amino-4-chloro-phenylamino)-9-isopropyl-9H...)

IC50: 5.20E+7nMAssay Description:Binding affinity to cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Dual specificity protein kinase CLK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL

BDBM50235040(AMINOPURVALANOL | CHEBI:38937)

EC50: 1.20E+4nMAssay Description:Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)

Kd: 126nMAssay Description:Binding affinity to GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair

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KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Serine/threonine-protein kinase 33(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay

BDBM50113745(3-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

EC50: 1.84E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase 33(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay

BDBM50113680((R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-puri...)

EC50: 2.49E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase 33(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay

BDBM50113682(3-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-...)

EC50: 2.86E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50113745(3-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2...)

EC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Solute carrier family 12 member 5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters

Curated by PubChem BioAssay

BDBM50113680((R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-puri...)

EC50: 9.54E+3nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Solute carrier family 12 member 5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters

Curated by PubChem BioAssay

BDBM50113680((R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-puri...)

EC50: 1.06E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair