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Found 31 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 4B1'
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50388532(CHEMBL2058833)
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50244440(CHEMBL4065122)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50543383(CHEMBL4634904)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP450More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50508662(CHEMBL4435025)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50017716(2,2-Diphenyl-pentanoic acid 2-diethylamino-ethyl e...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50512919(CHEMBL4554158)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50512922(CHEMBL4533700)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50512926(CHEMBL4554389)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50541296(CHEMBL4636169)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50589165(CHEMBL4288940)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50541318(CHEMBL4632688)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10)
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM368657(US10227350, Compound 105 | US10227350, Compound 10...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50511451(CHEMBL4570428)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP isoform (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM330295(Methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)me...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM264212((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM364746(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP450 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50543291(CHEMBL4644751)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50529361(CHEMBL4515137 | US10988487, Example 52)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50607543(CHEMBL5220590)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 4B1(Homo sapiens)
University Of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50585281(CHEMBL5079623)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed