Compile Data Set for Download or QSAR
maximum 50k data
Found 75 of ec50 data for polymerid = 1074,118,50001913
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273338((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273991((S)-1-(4-Fluorobenzyl)-5-(2-(pyrimidin-4-yloxymeth...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273927((S)-1-(4-Fluorobenzyl)-5-(2-(4-fluorophenoxymethyl...)
Affinity DataEC50:  8nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273929((S)-1-(4-Fluorobenzyl)-5-(2-(2,4-difluorophenoxyme...)
Affinity DataEC50:  13nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273928((S)-1-(4-Fluorobenzyl)-5-(2-(3-fluorophenoxymethyl...)
Affinity DataEC50:  13.5nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273990((S)-1-(4-Fluorobenzyl)-5-(2-(tetrahydro-2H-pyran-4...)
Affinity DataEC50:  14.4nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273989((S)-1-(4-Fluorobenzyl)-5-(2-(3,5-difluorophenoxyme...)
Affinity DataEC50:  16.8nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273339((S)-1-(4-Fluorobenzyl)-5-(2-((1-(2-fluoroethyl)-1H...)
Affinity DataEC50:  18.3nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10331((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)
Affinity DataEC50:  19.8nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50200305((S)-1-(4-iodobenzyl)-5-(2-phenoxymethyl-pyrrolidin...)
Affinity DataEC50:  25.3nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  28.2nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504311(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  29nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504311(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  29nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataEC50:  29.4nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504306(US11034717, Compound B)
Affinity DataEC50:  30nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504310(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  42nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504310(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  42nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273992((S)-1-(2-Propynyl)-5-(2-(2,4-difluorophenoxymethyl...)
Affinity DataEC50:  60.4nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273926(1-(4-Fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isati...)
Affinity DataEC50:  78.6nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504309(US11034717, Compound L1)
Affinity DataEC50:  150nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504309(US11034717, Compound L1)
Affinity DataEC50:  150nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504305(US11034717, Compound A)
Affinity DataEC50:  200nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504301(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  230nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504303(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  264nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRNA-binding protein FXR1(Human)
Intercept Pharmaceuticals

US Patent
LigandPNGBDBM504300(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  680nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77503(MLS000697060 | N-(3-allyl-6-sulfamoyl-1,3-benzothi...)
Affinity DataEC50: >3.16E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  4.50E+3nMpH: 7.4 T: 2°CAssay Description:Procaspase-7 activation assay; activation of procaspase-7 to caspase-7. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77499(2-(2-Methoxy-phenylamino)-8-methyl-quinoline-3-car...)
Affinity DataEC50:  9.49E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM32018(1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE | 4,5-diaceto...)
Affinity DataEC50:  1.48E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77506(2-keto-6-nitro-N-[1-(tetrahydrofuryl)ethyl]chromen...)
Affinity DataEC50:  2.02E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM71227(6-Amino-4-(1H-indol-3-yl)-3-methyl-1,4-dihydro-pyr...)
Affinity DataEC50:  2.78E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM33057(6-methyl-2-(1-naphthalenyl)-5-benzotriazolamine | ...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77498(5-(5-bromanylfuran-2-yl)-2,2-dimethyl-1,3,5,6-tetr...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77497(MLS000522781 | N-[2-[1-(4-methylbenzyl)benzimidazo...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM79431(MLS000519824 | SMR000130242 | [4-(4-fluorophenyl)-...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77509(2-[2-[5-methoxy-2-(4-methoxyphenyl)-1-benzothiophe...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM30895(2-(2-cyanoethylsulfanyl)-6-(5-methylfuran-2-yl)-4-...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77501((5E)-2-(4-methoxyphenyl)-5-(3,4,5-trimethoxybenzyl...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77500(2-(2,5-dimethyl-N-methylsulfonylanilino)-N-[4-(6-m...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM53108(2-[(6,7-dihydroxy-2-keto-chromen-4-yl)methylamino]...)
Affinity DataEC50: >8.52E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77495(4-(m-anisoylamino)-2,3-dihydrothiophene-5-carboxyl...)
Affinity DataEC50: >8.53E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM79432(1-[2,3-bis(chloranyl)phenyl]-3-chloranyl-4-(prop-2...)
Affinity DataEC50: >8.53E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM51685(4-methoxy-N-[(8-phenylmethoxy-2-quinolinyl)methyli...)
Affinity DataEC50: >8.53E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM79430(3-[2-[4-(dimethylamino)phenyl]-2-keto-ethyl]-6,7-d...)
Affinity DataEC50: >8.53E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
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