BDBM50273337 (S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin::CHEMBL456798
SMILES FCCn1cc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccccc2)nn1
InChI Key InChIKey=HYYDYCCTMBTVAC-SFHVURJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50273337
Affinity DataEC50: 16.7nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 28.2nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 6 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 16.7nMAssay Description:Inhibition of caspase 3 using Ac-DEVD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 12.2nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.97E+3nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12.4nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataEC50: 930nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair