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Found 455 of ic50 for UniProtKB: O60760
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385150(CHEMBL2035650)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385142(CHEMBL2035651)
Affinity DataIC50:  2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615811(CHEMBL5272869)
Affinity DataIC50:  2.40nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463698(CHEMBL4247050)
Affinity DataIC50:  3nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615823(CHEMBL5289520)
Affinity DataIC50:  3.10nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615812(CHEMBL5289730)
Affinity DataIC50:  3.80nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615791(CHEMBL5275536)
Affinity DataIC50:  3.90nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615775(CHEMBL5279860)
Affinity DataIC50:  3.90nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PDB3D3D Structure (crystal)
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615797(CHEMBL5282861)
Affinity DataIC50:  3.90nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM179403(US9126973, 8)
Affinity DataIC50:  4nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615779(CHEMBL5285125)
Affinity DataIC50:  4.40nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615795(CHEMBL5279371)
Affinity DataIC50:  4.60nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615800(CHEMBL5266142)
Affinity DataIC50:  4.60nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615813(CHEMBL5269778)
Affinity DataIC50:  4.70nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615802(CHEMBL5269001)
Affinity DataIC50:  4.80nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615792(CHEMBL5279720)
Affinity DataIC50:  4.90nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615824(CHEMBL5278680)
Affinity DataIC50:  5nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615825(CHEMBL5266618)
Affinity DataIC50:  5nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615796(CHEMBL5267588)
Affinity DataIC50:  5.10nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615778(CHEMBL5283521)
Affinity DataIC50:  5.30nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559393(CHEMBL4752221)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463701(CHEMBL4241885)
Affinity DataIC50:  6nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50576323(CHEMBL4866146)
Affinity DataIC50:  6nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM179422(US9126973, 19)
Affinity DataIC50:  6nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615782(CHEMBL5282228)
Affinity DataIC50:  6.40nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615798(CHEMBL5273656)
Affinity DataIC50:  6.40nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615810(CHEMBL5277213)
Affinity DataIC50:  6.60nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463702(CHEMBL3181890)
Affinity DataIC50:  7nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615799(CHEMBL5268479)
Affinity DataIC50:  7.10nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559403(CHEMBL4740750)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559399(CHEMBL4753053)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM250506(US9469627, 1)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50576316(CHEMBL4870703)
Affinity DataIC50:  8nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463704(CHEMBL4250602)
Affinity DataIC50:  8nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50526494(CHEMBL4439454)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385144(CHEMBL2035653)
Affinity DataIC50:  8.26nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615808(CHEMBL5289474)
Affinity DataIC50:  8.5nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM179375(US9126973, 1)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50576314(CHEMBL4864805)
Affinity DataIC50:  9nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615780(CHEMBL5285108)
Affinity DataIC50:  9.40nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PDB3D3D Structure (crystal)
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463699(CHEMBL4242281)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50526495(CHEMBL4452633)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559399(CHEMBL4753053)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50:  9.90nMMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50576324(CHEMBL4868339)
Affinity DataIC50:  10nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50463700(CHEMBL4239352)
Affinity DataIC50:  10nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615809(CHEMBL5288532)
Affinity DataIC50:  10nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM250507(US9469627, 2)
Affinity DataIC50:  11nMpH: 7.4Assay Description:I. Assay Solutions a. Preparation of 0.1M K2HPO4/KH2PO4 buffer (pH 7.4) Prepare 0.1 M KH2PO4 from 1M KH2PO4 (Sigma, Cat# P-8709) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50615794(CHEMBL5290809)
Affinity DataIC50:  11nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
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