Reaction Details Report a problem with these data
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Ligand
BDBM164395
Substrate
n/a
Meas. Tech.
PDE10A Inhibition Assay
Temperature
298.15±n/a K
IC50
0.33±n/a nM
Comments
extracted
Citation
Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent US9669029 Publication Date 6/6/2017
More Info.:
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:
PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:
n/a
Mol. Mass.:
39060.01
Organism:
Homo sapiens (Human)
Description:
Q9Y233[440-779]
Residue:
340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Inhibitor
Name:
BDBM164395
Synonyms:
US9669029, 98 8-Methoxy-5-methyl-2-{2-[1-(2-morpholin-4-yl-ethyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-[1,2,4]triazolo[1,5-a]pyridine
Type:
Small organic molecule
Emp. Form.:
C23H30N6O2S
Mol. Mass.:
454.588
SMILES:
COC1=CC=C(C)N2N=C(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)NC12 |t:2,4,8|