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Target
Aurora kinase B
Ligand
BDBM12986
Substrate
CHOCKtide
Meas. Tech.
Kinase SPA Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
1210±n/a nM
Citation
 Fancelli, D; Moll, J; Varasi, M; Bravo, R; Artico, R; Berta, D; Bindi, S; Cameron, A; Candiani, I; Cappella, P; Carpinelli, P; Croci, W; Forte, B; Giorgini, ML; Klapwijk, J; Marsiglio, A; Pesenti, E; Rocchetti, M; Roletto, F; Severino, D; Soncini, C; Storici, P; Tonani, R; Zugnoni, P; Vianello, P 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. J Med Chem 49:7247-51 (2006) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM12986
Synonyms:
4-(4-methylpiperazin-1-yl)-N-{5-[(2S)-2-phenylpropanoyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide | 5-Amido-pyrrolopyrazole 9e | CHEMBL217748
Type:
Small organic molecule
Emp. Form.:
C26H30N6O2
Mol. Mass.:
458.5554
SMILES:
C[C@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHOCKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
889.06
Organism:
n/a
Description:
n/a
Residue:
7
Sequence:
LRRWSLG