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Target
Aurora kinase A
Ligand
BDBM25686
Substrate
CHOCKtide
Meas. Tech.
Aurora Kinase SPA Assay
IC50
5250±n/a nM
Citation
 Andersen, CB; Wan, Y; Chang, JW; Riggs, B; Lee, C; Liu, Y; Sessa, F; Villa, F; Kwiatkowski, N; Suzuki, M; Nallan, L; Heald, R; Musacchio, A; Gray, NS Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Biol 3:180-92 (2008) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM25686
Synonyms:
4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(dimethylamino)ethyl]benzamide | aminothiazole analogue, 30
Type:
Small organic molecule
Emp. Form.:
C14H17BrN4OS
Mol. Mass.:
369.28
SMILES:
CN(C)CCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHOCKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
889.06
Organism:
n/a
Description:
n/a
Residue:
7
Sequence:
LRRWSLG