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Target
Beta-lactamase
Ligand
BDBM36640
Substrate
n/a
Meas. Tech.
Metallo-Beta-Lactamase Assay
pH
7±0
Temperature
310.15±0 K
IC50
1.9e+3± 2e+2 nM
Citation
 Toney, JH; Fitzgerald, PM; Grover-Sharma, N; Olson, SH; May, WJ; Sundelof, JG; Vanderwall, DE; Cleary, KA; Grant, SK; Wu, JK; Kozarich, JW; Pompliano, DL; Hammond, GG Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol 5:185-96 (1998) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Metallo-beta-lactamase
Type:
Protein
Mol. Mass.:
27160.75
Organism:
Bacteroides fragilis
Description:
Q8KZP2
Residue:
249
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTETLVNWVADSLHAKVTTFIPNHWHGDCIGGLGYLQKKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHPKQIVNQYIESTSKP
  
Inhibitor
Name:
BDBM36640
Synonyms:
CHEMBL26514 | L-159,061
Type:
Small organic molecule
Emp. Form.:
C26H24N6O2
Mol. Mass.:
452.5078
SMILES:
CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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