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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50046763
Substrate
n/a
Meas. Tech.
ChEMBL_161963 (CHEMBL769387)
IC50
26000±n/a nM
Citation
 Burke, TR; Lim, B; Marquez, VE; Li, ZH; Bolen, JB; Stefanova, I; Horak, ID Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck. J Med Chem 36:425-32 (1993) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50046763
Synonyms:
6,7-Dihydroxy-naphthalene-2-carboxylic acid amide | CHEMBL341423
Type:
Small organic molecule
Emp. Form.:
C11H9NO3
Mol. Mass.:
203.1941
SMILES:
NC(=O)c1ccc2cc(O)c(O)cc2c1
Structure:
Search PDB for entries with ligand similarity: