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Target
Stromelysin-1
Ligand
BDBM50241370
Substrate
n/a
Meas. Tech.
ChEMBL_104738 (CHEMBL710738)
Ki
230±n/a nM
Citation
 Esser, CK; Bugianesi, RL; Caldwell, CG; Chapman, KT; Durette, PL; Girotra, NN; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Owens, KA; Ponpipom, MM; Simeone, JP; Harrison, RK; Niedzwiecki, L; Becker, JW; Marcy, AI; Axel, MG; Christen, AJ; McDonnell, J; Moore, VL; Olszewski, JM; Saphos, C; Visco, DM; Hagmann, WK Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem 40:1026-40 (1997) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50241370
Synonyms:
(R)-2-[(S)-1-((S)-4-guanidino-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-propionic acid | CHEMBL251481 | L-702842
Type:
Small organic molecule
Emp. Form.:
C25H34N6O4
Mol. Mass.:
482.5753
SMILES:
[#6]-[#6@@H](-[#7]-[#6@@H](-[#6]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccccc1)-[#6](-[#8])=O
Structure:
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