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Target
Folate receptor alpha
Ligand
BDBM50059341
Substrate
n/a
Meas. Tech.
ChEMBL_68374 (CHEMBL678783)
Kd
136±n/a nM
Citation
 Varney, MD; Palmer, CL; Romines, WH; Boritzki, T; Margosiak, SA; Almassy, R; Janson, CA; Bartlett, C; Howland, EJ; Ferre, R Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition. J Med Chem 40:2502-24 (1997) [PubMed]  Article 
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50059341
Synonyms:
(S)-2-({5-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylsulfanyl)-propyl]-4-methyl-thiophene-2-carbonyl}-amino)-pentanedioic acid | CHEMBL315627
Type:
Small organic molecule
Emp. Form.:
C18H23N5O6S2
Mol. Mass.:
469.535
SMILES:
Cc1cc(sc1CCCSc1c(N)nc(N)[nH]c1=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Structure:
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