Reaction Details Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50061986
Substrate
n/a
Meas. Tech.
ChEMBL_195536 (CHEMBL800983)
IC50
20000±n/a nM
Citation
Qiu, YL; Ksebati, MB; Ptak, RG; Fan, BY; Breitenbach, JM; Lin, JS; Cheng, YC; Kern, ER; Drach, JC; Zemlicka, J (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity. J Med Chem 41:10-23 (1998) [PubMed] Article
More Info.:
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
Inhibitor
Name:
BDBM50061986
Synonyms:
CHEMBL305612 | [2-(6-Amino-purin-9-ylmethylene)-cyclopropyl]-methanol | {(2Z)-2-[(6-amino-9H-purin-9-yl)methylene]cyclopropyl}methanol | {2-[1-(6-Amino-purin-9-yl)-meth-(Z)-ylidene]-cyclopropyl}-methanol
Type:
Small organic molecule
Emp. Form.:
C10H11N5O
Mol. Mass.:
217.2272
SMILES:
Nc1ncnc2n(\C=C3\CC3CO)cnc12