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Target
Beta-1 adrenergic receptor
Ligand
BDBM50071291
Substrate
n/a
Meas. Tech.
ChEBML_37378
IC50
80±n/a nM
Citation
 Weber, AE; Ok, HO; Alvaro, RF; Candelore, MR; Cascieri, MA; Chiu, SH; Deng, L; Forrest, MJ; Hom, GJ; Hutchins, JE; Kao, J; MacIntyre, DE; Mathvink, RJ; McLoughlin, D; Miller, RR; Newbold, RC; Olah, TV; Parmee, ER; Perkins, L; Stearns, RA; Strader, CD; Szumiloski, J; Tang, YS; Tota, L; Fisher, MH 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties. Bioorg Med Chem Lett 8:2111-6 (1999) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50071291
Synonyms:
CHEMBL442172 | N-{4-[2-((S)-2-Hydroxy-3-phenoxy-propylamino)-ethyl]-phenyl}-4-iodo-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H25IN2O4S
Mol. Mass.:
552.425
SMILES:
O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1)COc1ccccc1
Structure:
Search PDB for entries with ligand similarity: