Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1F
Ligand
BDBM50091438
Substrate
n/a
Meas. Tech.
ChEMBL_2099 (CHEMBL617135)
Ki
3.2±n/a nM
Citation
 Witherington, J; Bordas, V; Cooper, DG; Forbes, IT; Gribble, AD; Ife, RJ; Berkhout, T; Gohil, J; Groot, PH Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists. Bioorg Med Chem Lett 11:2177-80 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1F
Synonyms:
5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.68
Organism:
Homo sapiens (Human)
Description:
5-HT1F HTR1F HUMAN::P30939
Residue:
366
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
  
Inhibitor
Name:
BDBM50091438
Synonyms:
(E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide | (E)-3-(3,4-dichlorophenyl)-N-(5-(4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl)pentyl)acrylamide | 3-(3,4-dichlorophenyl)-N-(5-(4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl)pentyl)acrylamide | CHEMBL432713 | TCMDC-139245
Type:
Small organic molecule
Emp. Form.:
C27H31Cl2N3O2
Mol. Mass.:
500.46
SMILES:
Oc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)\C=C\c4ccc(Cl)c(Cl)c4)CC3)c2c1
Structure:
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