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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50142657
Substrate
n/a
Meas. Tech.
ChEMBL_69355 (CHEMBL677591)
EC50
32±n/a nM
Citation
 Guo, T; Adang, AE; Dong, G; Fitzpatrick, D; Geng, P; Ho, KK; Jibilian, CH; Kultgen, SG; Liu, R; McDonald, E; Saionz, KW; Valenzano, KJ; van Straten, NC; Xie, D; Webb, ML Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis. Bioorg Med Chem Lett 14:1717-20 (2004) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50142657
Synonyms:
(3S,6S)-1-Heptyl-4,6-dimethyl-3-(3',4',5'-trimethoxy-biphenyl-4-ylmethyl)-piperazine-2,5-dione | CHEMBL279759
Type:
Small organic molecule
Emp. Form.:
C29H40N2O5
Mol. Mass.:
496.6383
SMILES:
CCCCCCCN1[C@@H](C)C(=O)N(C)[C@@H](Cc2ccc(cc2)-c2cc(OC)c(OC)c(OC)c2)C1=O
Structure:
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