Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM50157485
Substrate
n/a
Meas. Tech.
ChEMBL_429939 (CHEMBL916819)
IC50
3±n/a nM
Citation
 Steffan, RJ; Matelan, E; Ashwell, MA; Moore, WJ; Solvibile, WR; Trybulski, E; Chadwick, CC; Chippari, S; Kenney, T; Eckert, A; Borges-Marcucci, L; Keith, JC; Xu, Z; Mosyak, L; Harnish, DC Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. J Med Chem 47:6435-8 (2004) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50157485
Synonyms:
4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl]phenol | CHEMBL386502
Type:
Small organic molecule
Emp. Form.:
C17H15F3N2O
Mol. Mass.:
320.309
SMILES:
CC(C)n1nc(-c2ccc(O)cc2)c2cccc(c12)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: