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Target
Histamine H3 receptor
Ligand
BDBM50175828
Substrate
n/a
Meas. Tech.
ChEMBL_327753 (CHEMBL861794)
Ki
0.2±n/a nM
Citation
 Vaccaro, WD; Sher, R; Berlin, M; Shih, NY; Aslanian, R; Schwerdt, JH; McCormick, KD; Piwinski, JJ; West, RE; Anthes, JC; Williams, SM; Wu, RL; She, HS; Rivelli, MA; Mutter, JC; Corboz, MR; Hey, JA; Favreau, L Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorg Med Chem Lett 16:395-9 (2005) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50175828
Synonyms:
3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(3-fluorophenyl)propanamide | CHEMBL200382
Type:
Small organic molecule
Emp. Form.:
C18H23FN4O
Mol. Mass.:
330.3998
SMILES:
Fc1cccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)c1
Structure:
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