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Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM50273002
Substrate
n/a
Meas. Tech.
ChEMBL_514405 (CHEMBL971723)
EC50
280000±n/a nM
Citation
 Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Lüddens, H Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. J Med Chem 51:4430-48 (2008) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS
Type:
Enzyme
Mol. Mass.:
51770.21
Organism:
Rattus norvegicus (Rat)
Description:
P62813
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM50273002
Synonyms:
5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochloride | CHEMBL454608
Type:
Small organic molecule
Emp. Form.:
C3H5N3O2
Mol. Mass.:
115.0907
SMILES:
NCc1n[nH]c(=O)o1
Structure:
Search PDB for entries with ligand similarity: