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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50317234
Substrate
n/a
Meas. Tech.
ChEMBL_631356 (CHEMBL1105693)
IC50
8.7±n/a nM
Citation
 Boschelli, DH; Wang, D; Wang, Y; Wu, B; Honores, EE; Barrios Sosa, AC; Chaudhary, I; Golas, J; Lucas, J; Boschelli, F Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors. Bioorg Med Chem Lett 20:2924-7 (2010) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50317234
Synonyms:
(E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-morpholinoprop-1-enyl)quinoline-3-carbonitrile | CHEMBL1088679
Type:
Small organic molecule
Emp. Form.:
C25H24Cl2N4O3
Mol. Mass.:
499.389
SMILES:
COc1cc(Nc2c(cnc3cc(\C=C\CN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Structure:
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