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Target
Aurora kinase A
Ligand
BDBM50333667
Substrate
n/a
Meas. Tech.
ChEMBL_700207 (CHEMBL1647308)
IC50
>100000±n/a nM
Citation
 Morshed, MN; Cho, YS; Seo, SH; Han, KC; Yang, EG; Pae, AN Computational approach to the identification of novel Aurora-A inhibitors. Bioorg Med Chem 19:907-16 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50333667
Synonyms:
CHEMBL1643148 | N-(5-bromothiazol-2-yl)-2-(5-methoxybenzo[d]thiazol-2-ylthio)acetamide
Type:
Small organic molecule
Emp. Form.:
C13H10BrN3O2S3
Mol. Mass.:
416.336
SMILES:
COc1ccc2sc(SCC(=O)Nc3ncc(Br)s3)nc2c1
Structure:
Search PDB for entries with ligand similarity: