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Target
Ceramide glucosyltransferase
Ligand
BDBM50335387
Substrate
n/a
Meas. Tech.
ChEMBL_701780 (CHEMBL1656917)
IC50
100±n/a nM
Citation
 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett 2:119-123 (2011) [PubMed]  Article 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_MOUSE | Ugcg
Type:
PROTEIN
Mol. Mass.:
44844.15
Organism:
Mus musculus
Description:
ChEMBL_809643
Residue:
394
Sequence:
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50335387
Synonyms:
CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin
Type:
Small organic molecule
Emp. Form.:
C20H41NO5
Mol. Mass.:
375.5432
SMILES:
CCCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
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