Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50335638
Substrate
n/a
Meas. Tech.
ChEMBL_714655 (CHEMBL1663333)
IC50
46±n/a nM
Citation
 Pierre, F; Chua, PC; O'Brien, SE; Siddiqui-Jain, A; Bourbon, P; Haddach, M; Michaux, J; Nagasawa, J; Schwaebe, MK; Stefan, E; Vialettes, A; Whitten, JP; Chen, TK; Darjania, L; Stansfield, R; Anderes, K; Bliesath, J; Drygin, D; Ho, C; Omori, M; Proffitt, C; Streiner, N; Trent, K; Rice, WG; Ryckman, DM Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem 54:635-54 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50335638
Synonyms:
5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | CHEMBL1230165 | US8168651, Compound TABLE 16.17 | US9062043, Table 13, Compound 17 | US9062043, Table 20b, Compound 12
Type:
Small organic molecule
Emp. Form.:
C19H12ClN3O2
Mol. Mass.:
349.77
SMILES:
OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Structure:
Search PDB for entries with ligand similarity: