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Target
Bcl-2-like protein 2
Ligand
BDBM50339781
Substrate
n/a
Meas. Tech.
ChEMBL_735551 (CHEMBL1693159)
IC50
540±n/a nM
Citation
 Sleebs, BE; Czabotar, PE; Fairbrother, WJ; Fairlie, WD; Flygare, JA; Huang, DC; Kersten, WJ; Koehler, MF; Lessene, G; Lowes, K; Parisot, JP; Smith, BJ; Smith, ML; Souers, AJ; Street, IP; Yang, H; Baell, JB Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J Med Chem 54:1914-26 (2011) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50339781
Synonyms:
CHEMBL1689143 | N-(7-{4-[2-(4-Chloro-phenyl)-5,5-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}quinazolin-4-yl)-4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-nitro-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C45H53ClN8O4S2
Mol. Mass.:
869.537
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)Nc1ncnc2cc(ccc12)N1CCN(CC2=C(CCC(C)(C)C2)c2ccc(Cl)cc2)CC1 |r,t:47|
Structure:
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