Found 260 with Last Name = 'lowes' and Initial = 'k' 
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Plasmodium falciparum PMV assessed as fluorogenic substrate cleavage using DABCYL-RNKRTLAQKQ-E-EDANS as fluorogenic substrate after 120...More data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 6.20nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 7.10nM Kd: 1.40nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 13nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 14nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 14nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrateMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 20nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetPlasmepsin V(Plasmodium vivax)
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute Of Medical Research
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of Plasmodium vivax plasmepsin V by fluorogenic PEXEL cleavage assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 24nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
