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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50454434
Substrate
n/a
Meas. Tech.
ChEMBL_144168 (CHEMBL748943)
IC50
53000±n/a nM
Citation
 Hardick, DJ; Blagbrough, IS; Cooper, G; Potter, BV; Critchley, T; Wonnacott, S Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. J Med Chem 39:4860-6 (1997) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50454434
Synonyms:
Delcorine
Type:
Small organic molecule
Emp. Form.:
C26H41NO7
Mol. Mass.:
479.6062
SMILES:
[H][C@]12CC3C([C@H]1OC)[C@@]1(C[C@@H]2OC)OCO[C@@]11[C@@H](O)C2[C@]33C1N(CC)C[C@]2(COC)CC[C@@H]3OC |TLB:16:21:19:32.30.31,3:20:16.17:26.22.25,THB:32:20:16.17:26.22.25,6:5:3.2:8.9.10,23:22:19:32.30.31,22:21:8.4.3:19.17|
Structure:
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