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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50056946
Substrate
n/a
Meas. Tech.
ChEMBL_33102 (CHEMBL645955)
Ki
18±n/a nM
Citation
 el Ahmad, Y; Laurent, E; Maillet, P; Talab, A; Teste, JF; Dokhan, R; Tran, G; Ollivier, R New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands. J Med Chem 40:952-60 (1997) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51492.08
Organism:
CALF
Description:
adrenergic Alpha1 0 CALF
Residue:
466
Sequence:
MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
  
Inhibitor
Name:
BDBM50056946
Synonyms:
1-(4-Fluoro-phenyl)-4-[4-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butan-1-one | CHEMBL366388
Type:
Small organic molecule
Emp. Form.:
C24H29FN2O
Mol. Mass.:
380.4983
SMILES:
Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)C1CCCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: