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Target
Substance-P receptor
Ligand
BDBM50314377
Substrate
n/a
Meas. Tech.
ChEMBL_624545 (CHEMBL1110594)
IC50
0.14±n/a nM
Citation
 Bao, J; Lu, H; Morriello, GJ; Carlson, EJ; Wheeldon, A; Chicchi, GG; Kurtz, MM; Tsao, KL; Zheng, S; Tong, X; Mills, SG; DeVita, RJ Tetrahydroindolizinone NK1 antagonists. Bioorg Med Chem Lett 20:2354-8 (2010) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50314377
Synonyms:
(1S,2R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1-(4-fluorophenyl)-7-(pyridin-4-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one | CHEMBL1090752
Type:
Small organic molecule
Emp. Form.:
C29H23F7N2O2
Mol. Mass.:
564.4939
SMILES:
C[C@@H](O[C@H]1CN2C(CC(=CC2=O)c2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,c:8|
Structure:
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