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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM50385150
Substrate
n/a
Meas. Tech.
ChEMBL_823085 (CHEMBL2039156)
IC50
0.2±n/a nM
Citation
 Trujillo, JI; Kiefer, JR; Huang, W; Day, JE; Moon, J; Jerome, GM; Bono, CP; Kornmeier, CM; Williams, ML; Kuhn, C; Rennie, GR; Wynn, TA; Carron, CP; Thorarensen, A Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg Med Chem Lett 22:3795-9 (2012) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM50385150
Synonyms:
CHEMBL2035650
Type:
Small organic molecule
Emp. Form.:
C19H20F3N3O
Mol. Mass.:
363.3768
SMILES:
FC(F)(F)CN1CCC(CC1)NC(=O)c1ccc(nc1)-c1ccccc1
Structure:
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