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Target
Aurora kinase B
Ligand
BDBM50394785
Substrate
n/a
Meas. Tech.
ChEMBL_859542 (CHEMBL2168171)
EC50
3±n/a nM
Citation
 Liu, G; Abraham, S; Tran, L; Vickers, TD; Xu, S; Hadd, MJ; Quiambao, S; Holladay, MW; Hua, H; Ford Pulido, JM; Gunawardane, RN; Davis, MI; Eichelberger, SR; Apuy, JL; Gitnick, D; Gardner, MF; James, J; Breider, MA; Belli, B; Armstrong, RC; Treiber, DK Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index. J Med Chem 55:3250-60 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50394785
Synonyms:
CHEMBL2163404
Type:
Small organic molecule
Emp. Form.:
C27H29F2N9O2S
Mol. Mass.:
581.64
SMILES:
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C4)C(=O)N4CCC(F)(F)C4)cc3)nn3cccc23)n[nH]1 |r|
Structure:
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