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Target
Histamine H2 receptor
Ligand
BDBM50404956
Substrate
n/a
Meas. Tech.
ChEBML_84892
Ki
398±n/a nM
Citation
 Hoffman, JM; Pietruszkiewicz, AM; Habecker, CN; Phillips, BT; Bolhofer, WA; Cragoe, EJ; Torchiana, ML; Lumma, WC; Baldwin, JJ Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. J Med Chem 26:140-4 (1983) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40567.22
Organism:
Cavia porcellus (domestic guinea pig)
Description:
For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:
359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
  
Inhibitor
Name:
BDBM50404956
Synonyms:
CHEMBL284556
Type:
Small organic molecule
Emp. Form.:
C13H14N8OS2
Mol. Mass.:
362.433
SMILES:
[#6]-[#7]-c1ns(=O)nc1-[#7]-c1cccc(c1)-c1csc(\[#7]=[#6](/[#7])-[#7])n1
Structure:
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