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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50422932
Substrate
n/a
Meas. Tech.
ChEMBL_397361 (CHEMBL908026)
IC50
5.0±n/a nM
Citation
 Hertzog, DL; Al-Barazanji, KA; Bigham, EC; Bishop, MJ; Britt, CS; Carlton, DL; Cooper, JP; Daniels, AJ; Garrido, DM; Goetz, AS; Grizzle, MK; Guo, YC; Handlon, AL; Ignar, DM; Morgan, RO; Peat, AJ; Tavares, FX; Zhou, H The discovery and optimization of pyrimidinone-containing MCH R1 antagonists. Bioorg Med Chem Lett 16:4723-7 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50422932
Synonyms:
CHEMBL212958
Type:
Small organic molecule
Emp. Form.:
C25H24N4O5S
Mol. Mass.:
492.547
SMILES:
COc1cc(ccc1OCCN1CCCC1)-n1cnc2cc(sc2c1=O)-c1ccc(cc1)[N+]([O-])=O
Structure:
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