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Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Ligand
BDBM58113
Substrate
n/a
Meas. Tech.
ChEMBL_1288598 (CHEMBL3119218)
IC50
480±n/a nM
Citation
 Nakao, S; Mabuchi, M; Shimizu, T; Itoh, Y; Takeuchi, Y; Ueda, M; Mizuno, H; Shigi, N; Ohshio, I; Jinguji, K; Ueda, Y; Yamamoto, M; Furukawa, T; Aoki, S; Tsujikawa, K; Tanaka, A Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett 24:1071-4 (2014) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Synonyms:
ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1
Type:
PROTEIN
Mol. Mass.:
33382.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108024
Residue:
286
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
  
Inhibitor
Name:
BDBM58113
Synonyms:
2-(1H-Benzoimidazol-2-yl)-4-benzyl-5-methyl-2,4-dihydro-pyrazol-3-one | 2-(1H-benzimidazol-2-yl)-4-benzyl-5-methyl-2-pyrazolin-3-one | 2-(1H-benzimidazol-2-yl)-4-benzyl-5-methyl-4H-pyrazol-3-one | 2-(1H-benzimidazol-2-yl)-5-methyl-4-(phenylmethyl)-4H-pyrazol-3-one | CHEMBL3114983 | MLS000762809 | SMR000439826 | cid_3915969
Type:
Small organic molecule
Emp. Form.:
C18H16N4O
Mol. Mass.:
304.3458
SMILES:
Cc1[nH]n(-c2nc3ccccc3[nH]2)c(=O)c1Cc1ccccc1
Structure:
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